5-Bromo-3-fluoropyridin-2(1H)-one

Name: 5-Bromo-3-fluoropyridin-2(1H)-one
Brand: ChemScene
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CAS No. 156772-63-3
Cat. No. CS-W007067
Molecule weight191.99
Purity≥97%
MDL No.MFCD06659498

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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5-Bromo-3-fluoropyridin-2(1H)-one|CS-W007067

Structure of 156772-63-3

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General Information

CAS No. 156772-63-3
Cat. No. CS-W007067
Purity ≥97%
MDL No. MFCD06659498
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₃BrFNO
Molecular Weight 191.99
Synonym(s) 5-Bromo-3-fluoropyridin-2-ol
SMILES O=C1C(F)=CC(Br)=CN1

Description

5-Bromo-3-fluoropyridin-2(1H)-one features a fused heterocyclic core with complementary halogen substituents enabling precise functionalization. The bromine at C5 and fluorine at C3 facilitate cross-coupling reactions, while the lactam carbonyl enhances solubility and stability under standard conditions. This scaffold integrates readily into bioactive molecules for medicinal chemistry applications.

Application

5-Bromo-3-fluoropyridin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its bromine functionality. The fluorine substituent enhances metabolic stability and modulates electronic properties. Its pyridinone core provides hydrogen-bonding capability and facilitates incorporation into bioactive heterocycles. Bench-stable and compatible with standard purification methods, it functions effectively in the synthesis of kinase inhibitors and other pharmaceutical scaffolds.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 32.86
LogP 1.2765
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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5-Bromo-3-fluoropyridin-2(1H)-one

CAS No. 156772-63-3

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