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Structure of 1572-98-1
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Ethyl 2-cyano-2-methylpropanoate features a sterically hindered α-cyano ester core that enables efficient Michael additions and conjugate functionalizations. The nitrile group enhances reactivity in nucleophilic transformations, while the ethyl ester provides a handle for selective derivatization. This bench-stable reagent integrates readily into synthetic sequences requiring robust C–C bond formation under mild conditions.
Ethyl 2-cyano-2-methylpropanoate serves as a robust synthon for quaternary carbon centers, enabling efficient construction of sterically hindered alkylated scaffolds. Its nitrile and ester functionalities exhibit high tolerance to diverse reaction conditions, facilitating sequential transformations in multistep synthesis. The molecule demonstrates excellent bench stability and simplifies purification due to low volatility and minimal byproduct formation. It functions effectively in Michael additions, Mannich reactions, and as a key building block in the synthesis of heterocyclic frameworks and bioactive analogs.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H227-H302+H312+H332-H315-H319
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Precautionary Statements : P210-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P403-P501
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Lot numbers can be found on the outside label of a product: