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CS-W001157 4
Total: USD 88.00

2-Bromoquinoline-4-carboxylic acid

  • CAS No. 15733-87-6

  • Cat. No. CS-W021629
  • Purity≥95%
  • MDL No.MFCD08705669
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Bromoquinoline-4-carboxylic acid|CS-W021629

Structure of 15733-87-6

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Description

2-Bromoquinoline-4-carboxylic acid features a brominated quinoline scaffold with a carboxylic acid group at the 4-position, enabling direct functionalization in cross-coupling and bioconjugation workflows. The electron-deficient heterocycle pairs effectively with palladium catalysts, while the acidic proton facilitates salt formation and purification under standard conditions. This compound serves as a key intermediate for pharmaceutical and agrochemical lead discovery.

Application

2-Bromoquinoline-4-carboxylic acid serves as a versatile building block for the synthesis of quinoline-based pharmaceuticals and functional materials. Its bromine substituent enables palladium-catalyzed cross-coupling reactions, while the carboxylic acid group facilitates derivatization via amide, ester, or acyl chloride formation. The molecule exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthetic campaigns in medicinal chemistry and process development.

General Information

  • CAS No. 15733-87-6
  • Cat. No. CS-W021629
  • Purity ≥95%
  • MDL No. MFCD08705669
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₆BrNO₂
  • Molecular Weight 252.06
  • Synonym(s) 4-Quinolinecarboxylic acid,2-bromo
  • SMILES BrC2=NC1=CC=CC=C1C(=C2)C(=O)O

Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.6955
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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