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CS-W001157 4
Total: USD 88.00

4,4'-Oxybis(methylbenzene)

  • CAS No. 1579-40-4

  • Cat. No. CS-0153050
  • Purity≥98%
  • MDL No.MFCD00025979

*For research and further manufacturing use only, not for direct human use.

4,4'-Oxybis(methylbenzene)|CS-0153050

Structure of 1579-40-4

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General Information

  • CAS No. 1579-40-4
  • Cat. No. CS-0153050
  • Purity ≥98%
  • MDL No. MFCD00025979
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₄O
  • Molecular Weight 198.26
  • Synonym(s) p-Tolyl ether
  • SMILES CC1=CC=C(C=C1)OC2=CC=C(C)C=C2

Description

4-Fluoro-thalidomide is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966).

Synthesis

  • Route1

    References

    • Synthetic Communications, , vol. 38, # 17 p. 3023 - 3031
  • Route2
    • null|null
      106-44-5
    • null|null
      106-38-7
    • ~87%
    • 4,4'-Oxybis(methylbenzene)|CS-0153050
      1579-40-4

    References

    • Bulletin of the Korean Chemical Society, , vol. 34, # 12 p. 3915 - 3918
  • Route3
    • null|null
      106-38-7
    • ~78%
    • 4,4'-Oxybis(methylbenzene)|CS-0153050
      1579-40-4

    References

    • Tetrahedron Letters, , vol. 48, # 3 p. 473 - 476

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS08,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H315-H319-H335-H372-H410
Precautionary Statements : P260-P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P362+P364-P391-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   4.09574
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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