(2E)-TCO-PNB ester

Name: (2E)-TCO-PNB ester
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1580501-97-8
Cat. No. CS-0145750
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 1580501-97-8

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Description

This (2E)-TCO-PNB ester features a photochemically reactive tetrazine cyclooctene moiety paired with a p-nitrobenzyl leaving group, enabling rapid, bioorthogonal conjugation under mild conditions. The electron-deficient TCO unit facilitates efficient inverse electron-demand Diels-Alder reactions with tetrazines, while the bench-stable PNB ester ensures reliable handling and controlled release. Ideal for site-specific labeling in complex biological systems.

Application

The (2E)-TCO-PNB ester serves as a stable, bench-ready reagent for bioorthogonal conjugation, enabling rapid and selective reaction with tetrazines under mild conditions. Its (2E)-configured trans-cyclooctene core provides high reactivity in inverse electron-demand Diels-Alder (IEDDA) reactions, while the p-nitrobenzyl (PNB) ester group ensures clean activation and efficient release of functionalized payloads. Ideal for labeling biomolecules and constructing modular probes, it combines excellent stability with predictable transformation kinetics.

General Information

CAS No. 1580501-97-8
Cat. No. CS-0145750
Purity ≥98%
MDL No. None
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₅H₁₇NO₅
Molecular Weight 291.30
Synonym(s) None
SMILES O=C(OC1=CC=C([N+]([O-])=O)C=C1)OC2/C=C/CCCCC2

Computational Chemistry Data

TPSA 78.67
LogP 3.9991
H_Acceptors 5
H_Donors 0
Rotatable_Bonds 3

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P501

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Other Classifications

Life Science Linker Cleavable Linkers

Life Science Click Chemistry Reagents TCO

Chemical Biology Pharmaceutical Development and Drug Discovery Research Conjugation Chemistry/Click Chemistry Copper-free Click Reaction Reagents

Chemical Biology Pharmaceutical Development and Drug Discovery Research Conjugation Chemistry/Click Chemistry trans-Cyclooctenes (TCO)

Chemical Biology Conjugation Chemistry/Click Chemistry Copper-free Click Reaction Reagents

Chemical Biology Conjugation Chemistry/Click Chemistry trans-Cyclooctenes (TCO)

Biochemistry Biochemicals and Reagents Bioconjugation Copper-free Click Reaction Reagents

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(2E)-TCO-PNB ester

CAS No. 1580501-97-8

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