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N-Desbutyl Bupivacaine

  • CAS No. 15883-20-2

  • Cat. No. CS-0038135
  • Purity≥98%
  • MDL No.MFCD01701244

*For research and further manufacturing use only, not for direct human use.

N-Desbutyl Bupivacaine|CS-0038135

Structure of 15883-20-2

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General Information

  • CAS No. 15883-20-2
  • Cat. No. CS-0038135
  • Purity ≥98%
  • MDL No. MFCD01701244
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₀N₂O
  • Molecular Weight 232.32
  • Synonym(s) Desbutylbupivacaine
  • SMILES CC1=CC=CC(C)=C1NC(C2CCCCN2)=O

Description

1-Octanol is one of the key flavor constituents of mushrooms.

Application

N-Desbutyl Bupivacaine serves as a key metabolite and synthetic intermediate in local anesthetic research, featuring a primary amine for further derivatization. Its structure enables straightforward functional group manipulation under standard conditions, facilitating studies on metabolic pathways and structure-activity relationships. The compound exhibits good bench stability and is compatible with common purification techniques, making it a practical choice for medicinal chemistry workflows involving amide bond formation or scaffold diversification.

Synthesis

  • Route1
    • N-(2,6-Dimethylphenyl)-2-picolinamide|CS-0213343
      39627-98-0
    • ~72%
    • In-stock
      N-Desbutyl Bupivacaine|CS-0038135
      15883-20-2

    References

    • PHARMATHEN S.A. Patent: WO2009/89842 A1, 2009 ; Location in patent: Page/Page column 5-6 ;
  • Route2
    • (2S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide Ropivacaine Impurity|CS-0229592
      27262-40-4
    • ~%
    • In-stock
      N-Desbutyl Bupivacaine|CS-0038135
      15883-20-2

    References

    • Organic Process Research and Development, , vol. 16, # 2 p. 343 - 352
  • Route3

    References

    • European Journal of Medicinal Chemistry, , vol. 33, # 1 p. 23 - 31

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.13
  • LogP   2.38404
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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