Bis-propargyl-PEG4

Name: Bis-propargyl-PEG4
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 159428-42-9
Cat. No. CS-0077872
Purity≥95%
MDL No.MFCD22201533

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HazMat Fee

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The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 159428-42-9

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Description

Bis-propargyl-PEG4 delivers a bifunctional, linear PEG spacer with terminal propargyl groups, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC). This water-soluble linker facilitates site-specific conjugation in biomolecular labeling, polymer functionalization, and bioconjugate synthesis under mild conditions.

Application

Bis-propargyl-PEG4 serves as a versatile bifunctional linker for copper-catalyzed azide-alkyne cycloaddition (CuAAC) and other click chemistry applications. Its two terminal propargyl groups enable efficient conjugation of biomolecules, polymers, or solid-phase supports with high regioselectivity. The PEG4 spacer provides enhanced solubility and flexibility, while the compound exhibits excellent bench stability and ease of purification—ideal for synthesizing functionalized scaffolds in medicinal chemistry and materials science workflows.

General Information

CAS No. 159428-42-9
Cat. No. CS-0077872
Purity ≥95%
MDL No. MFCD22201533
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₄H₂₂O₅
Molecular Weight 270.32
Synonym(s) None
SMILES C#CCOCCOCCOCCOCCOCC#C

Computational Chemistry Data

TPSA 46.15
LogP 0.3358
H_Acceptors 5
H_Donors 0
Rotatable_Bonds 14

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Other Classifications

Building Blocks Functional Group PEG

Building Blocks Skeleton Fatty chain compounds

Life Science Linker Alkyne PEG

Life Science Linker Propargyl PEG

Life Science Click Chemistry Reagents

Chemical Biology Pharmaceutical Development and Drug Discovery Research Conjugation Chemistry/Click Chemistry PEG Azides/Alkynes

Chemical Biology Conjugation Chemistry/Click Chemistry PEG Azides/Alkynes

Chemical Biology PEGylation Monofunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation Heterobifunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

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Bis-propargyl-PEG4

CAS No. 159428-42-9

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