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CS-W001157 4
Total: USD 88.00

4-Chloro-3,5-dimethyl-1H-pyrazole

  • CAS No. 15953-73-8

  • Cat. No. CS-0153639
  • Molecule weight130.58
  • Purity≥98%
  • MDL No.MFCD00825711

*For research and further manufacturing use only, not for direct human use.

4-Chloro-3,5-dimethyl-1H-pyrazole|CS-0153639

Structure of 15953-73-8

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General Information

  • CAS No. 15953-73-8
  • Cat. No. CS-0153639
  • Purity ≥98%
  • MDL No. MFCD00825711
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇ClN₂
  • Molecular Weight 130.58
  • Synonym(s) None
  • SMILES CC1=C(C(=NN1)C)Cl

Description

4-Chloro-3,5-dimethyl-1H-pyrazole features a sterically hindered pyrazole core with electron-withdrawing chlorine and methyl substituents, enhancing stability and modulating reactivity. This scaffold integrates readily into bioactive molecules, offering tunable polarity for medicinal chemistry applications.

Application

4-Chloro-3,5-dimethyl-1H-pyrazole serves as a versatile heterocyclic building block in medicinal chemistry and agrochemical synthesis. Its electron-deficient pyrazole core enables reliable coupling reactions, while the chlorine substituent provides a site for nucleophilic displacement. The methyl groups enhance solubility and stability, facilitating straightforward purification and scalability in multi-step syntheses.

Synthesis

  • Route1
    • null|null
      67-51-6
    • ~96%
    • In-stock
      4-Chloro-3,5-dimethyl-1H-pyrazole|CS-0153639
      15953-73-8

    References

    • Stefani, Helio A.; Pereira, Claudio M. P.; Almeida, Roberta B.; Braga, Rodolpho C.; Guzen, Karla P.; Cella, Rodrigo Tetrahedron Letters, 2005 , vol. 46, # 40 p. 6833 - 6837
  • Route2
    • null|null
      1694-29-7
    • ~89%
    • In-stock
      4-Chloro-3,5-dimethyl-1H-pyrazole|CS-0153639
      15953-73-8

    References

    • Malbosc, Francois; Chauby, Valerie; Serra-Le Berre, Carole; Etienne, Michel; Daran, Jean-Claude; Kalck, Philippe European Journal of Inorganic Chemistry, 2001 , # 10 p. 2689 - 2697
  • Route3

    References

    • Russian Journal of Organic Chemistry, , vol. 35, # 9 p. 1363 - 1371

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   1.67994
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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