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Structure of 15965-54-5
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2-Chloro-6-methoxy-1H-benzimidazole integrates a chlorine atom at the 2-position and a methoxy group at the 6-position, conferring enhanced electron-withdrawing character and improved solubility in polar organic solvents. This scaffold serves as a key building block in medicinal chemistry, particularly for targeting kinase pathways and modulating receptor activity.
2-Chloro-6-methoxy-1H-benzimidazole serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. Its ortho-chloro group exhibits high reactivity in Suzuki, Stille, and Buchwald–Hartwig transformations, while the methoxy substituent enhances solubility and modulates electronic properties. The benzimidazole core provides metabolic stability and favorable binding interactions in target-directed synthesis. This compound offers excellent bench stability, straightforward purification, and compatibility with diverse reaction conditions, making it ideal for rapid scaffold diversification in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: