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CS-W001157 4
Total: USD 88.00

5-Fluoro-2-iodopyridine

  • CAS No. 159870-80-1

  • Cat. No. CS-W022378
  • Purity≥95%
  • MDL No.MFCD07787574

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-2-iodopyridine|CS-W022378

Structure of 159870-80-1

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General Information

  • CAS No. 159870-80-1
  • Cat. No. CS-W022378
  • Purity ≥95%
  • MDL No. MFCD07787574
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃FIN
  • Molecular Weight 222.99
  • Synonym(s) 2-Iodo-5-Fluoropyridine
  • SMILES IC1=NC=C(F)C=C1

Description

5-Fluoro-2-iodopyridine serves as a key building block in cross-coupling chemistry, featuring a reactive iodide and electron-deficient pyridine ring. This combination enables efficient palladium-catalyzed transformations, including Suzuki-Miyaura and Buchwald-Hartwig reactions. The fluorine substituent enhances metabolic stability and modulates electronic properties in pharmaceutical intermediates.

Application

5-Fluoro-2-iodopyridine serves as a versatile building block in cross-coupling chemistry, enabling efficient construction of biaryl and heterocyclic scaffolds. The ortho-iodo group facilitates palladium-catalyzed reactions such as Suzuki, Stille, and Negishi couplings, while the meta-fluoro substituent offers complementary reactivity for further functionalization. Its bench-stable nature and predictable regioselectivity make it ideal for medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.8253
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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