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Structure of 159981-19-8
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6-(2,2,2-Trifluoroethoxy)nicotinaldehyde features a trifluoromethyl ether substituent that enhances metabolic stability and lipophilicity. This electron-deficient aldehyde integrates readily into synthetic scaffolds for pharmaceutical intermediates, offering improved solubility in polar organic solvents and robust performance under standard bench conditions.
6-(2,2,2-Trifluoroethoxy)nicotinaldehyde serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and functionalized pharmaceutical intermediates. Its trifluoroethoxy group enhances metabolic stability and modulates lipophilicity, while the aldehyde functionality supports efficient derivatization via reductive amination, imine formation, or condensation reactions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for scalable synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: