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CS-W001157 4
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(Iodoethynyl)triisopropylsilane

  • CAS No. 160481-43-6

  • Cat. No. CS-0377202
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(Iodoethynyl)triisopropylsilane|CS-0377202

Structure of 160481-43-6

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General Information

  • CAS No. 160481-43-6
  • Cat. No. CS-0377202
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₁ISi
  • Molecular Weight 308.27
  • Synonym(s) Triisopropylsilyliodoacetylene
  • SMILES IC#C[Si](C(C)C)(C(C)C)C(C)C

Description

(Iodoethynyl)triisopropylsilane features a terminal alkyne anchored by a robust triisopropylsilyl group, enabling stable coupling in transition-metal-catalyzed reactions. This bench-stable reagent facilitates efficient C–C bond formation under mild conditions, particularly in Sonogashira and copper-free click chemistry applications.

Application

(Iodoethynyl)triisopropylsilane serves as a stable, bench-ready building block for Sonogashira coupling reactions. Its triisopropylsilyl group provides enhanced steric protection and improved solubility, facilitating efficient cross-coupling with aryl and vinyl halides under mild conditions. The terminal alkyne functionality enables straightforward access to conjugated enynes and functionalized alkynyl scaffolds, making it a reliable reagent for the synthesis of complex molecular architectures in medicinal chemistry and materials science.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 2924
Class : 3,8
Packing Group : Ⅲ
Hazard Statements : H225-H302-H312-H315-H318-H332-H335
Precautionary Statements : P210-P240-P241-P242-P243-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   4.6003
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   3

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