Alloc-Val-Cit-PAB-OH

Name: Alloc-Val-Cit-PAB-OH
Brand: ChemScene
Availability: InStock
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CAS No. 1608127-09-8
Cat. No. CS-0621798
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 1608127-09-8

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Description

Alloc-Val-Cit-PAB-OH is a cleavable linker peptide designed for antibody-drug conjugate (ADC) applications. Featuring a labile hydrazine bond, it enables efficient intracellular release of payload upon reduction in the tumor microenvironment. The Alloc group provides orthogonal protection, while the PAB moiety enhances solubility and stability during conjugation workflows.

Application

Alloc-Val-Cit-PAB-OH serves as a well-established linker for antibody-drug conjugates, enabling site-specific payload attachment via hydrazine ligation. The Alloc group provides orthogonal protection, while the Val-Cit dipeptide ensures enzymatic cleavage in target cells. This stable, bench-ready intermediate facilitates efficient conjugation and demonstrates reliable performance in preclinical ADC development workflows.

General Information

CAS No. 1608127-09-8
Cat. No. CS-0621798
Purity ≥98%
MDL No. None
Storage 4°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₂H₃₃N₅O₆
Molecular Weight 463.53
Synonym(s) None
SMILES CC(C)[C@@H](C(=O)N[C@@H](CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)CO)NC(=O)OCC=C

Computational Chemistry Data

TPSA 171.88
LogP 0.9875
H_Acceptors 6
H_Donors 6
Rotatable_Bonds 13

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Other Classifications

Building Blocks Functional Group Urea

Building Blocks Functional Group Olefins

Building Blocks Functional Group Amide

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Chemical Biology Pharmaceutical Development and Drug Discovery Research Bioconjugation Enzyme Cleavable Linkers (Cleave Motif)

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Biochemicals and Reagents Bioconjugation Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Key Words

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Alloc-Val-Cit-PAB-OH

CAS No. 1608127-09-8

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