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Structure of 16115-08-5
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4,6-Dimethylpyridin-2-ol features a pyridinol core with methyl groups at the 4 and 6 positions, conferring enhanced stability and steric protection to the phenolic hydroxyl. This configuration enables selective metal coordination and facilitates use in ligand design for transition metal catalysis, particularly in palladium-catalyzed cross-coupling processes where robustness under reaction conditions is critical.
4,6-Dimethylpyridin-2-ol serves as a versatile building block in medicinal chemistry, enabling the synthesis of substituted pyridine scaffolds through standard functional group transformations. Its ortho-hydroxyl group facilitates metal-catalyzed coupling reactions and acts as a directing group in C–H activation processes. The methyl substituents enhance metabolic stability and influence electronic properties, while the compound exhibits good bench stability and ease of purification, making it suitable for iterative synthetic campaigns in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H335-H320
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Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P312-P330-P332+P313-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: