Pyridine-3-sulfonyl chloride

Name: Pyridine-3-sulfonyl chloride
Brand: ChemScene
Availability: InStock
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CAS No. 16133-25-8
Cat. No. CS-W008940
Purity≥98%
MDL No.MFCD03452747

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FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Description

Pyridine-3-sulfonyl chloride delivers a reactive sulfonyl electrophile for C–H functionalization and heterocycle synthesis. This bench-stable reagent features a nitrogen-rich pyridine scaffold that enhances solubility in polar solvents and facilitates selective coupling with nucleophiles. The para-positioned sulfonyl group enables efficient incorporation into bioactive scaffolds, offering enhanced metabolic stability and improved pharmacokinetic profiles in medicinal chemistry applications.

Application

Pyridine-3-sulfonyl chloride serves as a versatile sulfonylating agent for the efficient introduction of the pyridine-3-sulfonyl group into organic molecules. It facilitates nucleophilic substitution reactions with amines and alcohols under mild conditions, enabling rapid access to sulfonamide and sulfonate derivatives. The compound exhibits good bench stability and ease of purification, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

General Information

CAS No. 16133-25-8
Cat. No. CS-W008940
Purity ≥98%
MDL No. MFCD03452747
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄ClNO₂S
Molecular Weight 177.61
Synonym(s) None
SMILES O=S(C1=CC=CN=C1)(Cl)=O

Computational Chemistry Data

TPSA 47.03
LogP 1.0091
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3265
Class : 8	Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P280-P301+P330+P331

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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Pyridine-3-sulfonyl chloride

CAS No. 16133-25-8

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