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CS-W001157 4
Total: USD 88.00

4-​Chloro-​2-​butenoic acid

  • CAS No. 16197-90-3

  • Cat. No. CS-0139553
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-​Chloro-​2-​butenoic acid|CS-0139553

Structure of 16197-90-3

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Description

4-Chloro-2-butenoic acid features a conjugated double bond system adjacent to the carboxylic acid group, enhancing its reactivity in Michael additions and enolate chemistry. The chlorine substituent imparts electron-withdrawing character, stabilizing adjacent anionic intermediates. This structure enables efficient incorporation into complex synthetic scaffolds under mild conditions.

Application

4-Chloro-2-butenoic acid serves as a versatile building block in synthetic organic chemistry, enabling the construction of substituted pyrrolidines and other nitrogen-containing heterocycles via Michael addition or cyclization protocols. Its conjugated enoic acid functionality offers enhanced reactivity in nucleophilic additions and facilitates straightforward derivatization under mild conditions. The molecule exhibits good bench stability and is amenable to purification by standard chromatographic techniques, making it well-suited for iterative synthesis workflows in medicinal chemistry and process development.

General Information

  • CAS No. 16197-90-3
  • Cat. No. CS-0139553
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅ClO₂
  • Molecular Weight 120.53
  • Synonym(s) AMMA-CHLOROCROTONICACID
  • SMILES O=C(O)/C=C/CCl

Computational Chemistry Data

  • TPSA   37.3
  • LogP   0.866
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group :
Hazard Statements : H290-H314
Precautionary Statements : P234-P260-P264-P280-P301+P330+P331-P304+P340-P363-P390-P405-P406-P501

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