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Structure of 162046-65-3
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tert-Butyl 4-(chlorosulfonyl)piperazine-1-carboxylate features a reactive chlorosulfonyl group enabling direct sulfonamide formation. This bench-stable, moisture-tolerant reagent integrates readily into synthetic sequences requiring piperazine-based scaffolds. The tert-butyl ester offers convenient protection and subsequent deprotection under mild acidic conditions.
tert-Butyl 4-(chlorosulfonyl)piperazine-1-carboxylate serves as a versatile building block for the synthesis of sulfonamide-containing heterocycles. Its chlorosulfonyl group enables efficient nucleophilic substitution with amines, facilitating the construction of piperazine-based scaffolds common in medicinal chemistry. The tert-butoxycarbonyl (Boc) group provides stability and ease of removal under mild acidic conditions, enhancing purification and functional group compatibility in multi-step syntheses.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H314
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501
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Lot numbers can be found on the outside label of a product: