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Structure of 1621096-79-4
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TCO-PEG4-NHS ester enables site-specific bioconjugation through rapid, inverse electron-demand Diels-Alder reactions with tetrazines. This water-soluble linker features a PEG4 spacer that enhances solubility and reduces non-specific binding, while the NHS ester facilitates efficient coupling to primary amines under physiological conditions.
TCO-PEG4-NHS ester serves as a versatile, water-soluble linker for bioconjugation, enabling efficient coupling to primary amines under physiological conditions. The tetrazine cycloaddition handle facilitates rapid, bioorthogonal labeling, while the PEG4 spacer enhances solubility and reduces non-specific binding. Its stability in aqueous environments and ease of purification make it ideal for conjugating peptides, proteins, and oligonucleotides in diagnostic and therapeutic applications.
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Lot numbers can be found on the outside label of a product: