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CS-W001157 4
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TCO-PEG4-NHS ester

  • CAS No. 1621096-79-4

  • Cat. No. CS-0168110
  • Purity≥98%
  • MDL No.MFCD28118912
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

TCO-PEG4-NHS ester|CS-0168110

Structure of 1621096-79-4

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Description

TCO-PEG4-NHS ester enables site-specific bioconjugation through rapid, inverse electron-demand Diels-Alder reactions with tetrazines. This water-soluble linker features a PEG4 spacer that enhances solubility and reduces non-specific binding, while the NHS ester facilitates efficient coupling to primary amines under physiological conditions.

Application

TCO-PEG4-NHS ester serves as a versatile, water-soluble linker for bioconjugation, enabling efficient coupling to primary amines under physiological conditions. The tetrazine cycloaddition handle facilitates rapid, bioorthogonal labeling, while the PEG4 spacer enhances solubility and reduces non-specific binding. Its stability in aqueous environments and ease of purification make it ideal for conjugating peptides, proteins, and oligonucleotides in diagnostic and therapeutic applications.

General Information

  • CAS No. 1621096-79-4
  • Cat. No. CS-0168110
  • Purity ≥98%
  • MDL No. MFCD28118912
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₄H₃₈N₂O₁₀
  • Molecular Weight 514.57
  • Synonym(s) None
  • SMILES O=C(OC1CC/C=C/CCC1)NCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O

Computational Chemistry Data

  • TPSA   138.93
  • LogP   1.6652
  • H_Acceptors   10
  • H_Donors   1
  • Rotatable_Bonds   17

Safety Information

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GHS Pictogram : N/A
GHS No : N/A
Signal Word : N/A
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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