(R)-tert-Butyl 2-methyl-3-oxopiperazine-1-carboxylate

Name: (R)-tert-Butyl 2-methyl-3-oxopiperazine-1-carboxylate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1629229-82-8
Cat. No. CS-0162178
Purity≥98%
MDL No.MFCD28969589

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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(R)-tert-Butyl 2-methyl-3-oxopiperazine-1-carboxylate|CS-0162178

Structure of 1629229-82-8

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Description

(R)-tert-Butyl 2-methyl-3-oxopiperazine-1-carboxylate is a chiral piperazine scaffold featuring a stereodefined (R)-configuration at the C2 position. The molecule bears a ketone at C3 and a tert-butyloxycarbonyl (Boc) group, enabling selective derivatization. This stable, bench-ready building block integrates efficiently into complex heterocycles for medicinal chemistry applications.

Application

(R)-tert-Butyl 2-methyl-3-oxopiperazine-1-carboxylate serves as a versatile chiral building block for the synthesis of piperazine-based pharmaceutical intermediates. Its well-defined stereochemistry and stable tert-butyl carbamate handle enable straightforward functionalization, while the 3-oxo group facilitates nucleophilic addition and ring expansion reactions. The molecule exhibits excellent bench stability and compatibility with standard purification protocols, making it ideal for iterative synthetic sequences in medicinal chemistry and process development workflows.

General Information

CAS No. 1629229-82-8
Cat. No. CS-0162178
Purity ≥98%
MDL No. MFCD28969589
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₈N₂O₃
Molecular Weight 214.26
Synonym(s) tert-butyl (2R)-2-methyl-3-oxopiperazine-1-carboxylate
SMILES O=C(N1[C@H](C)C(NCC1)=O)OC(C)(C)C

Computational Chemistry Data

TPSA 58.64
LogP 0.7418
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-tert-Butyl 2-methyl-3-oxopiperazine-1-carboxylate

CAS No. 1629229-82-8

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