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Structure of 162959-94-6
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1-(Thiophen-2-yl)cyclopropanecarboxylic acid features a rigid cyclopropane ring fused to a thiophene moiety, delivering enhanced structural rigidity and electron-rich character. This scaffold enables efficient integration into bioactive molecules, particularly in medicinal chemistry applications where metabolic stability and defined conformation are critical. The carboxylic acid group supports direct derivatization or salt formation for improved solubility and handling under standard conditions.
1-(Thiophen-2-yl)cyclopropanecarboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds. Its cyclopropyl carboxylic acid motif offers enhanced metabolic stability and conformational rigidity, while the thiophene ring provides π-stacking and dipole interactions. The compound exhibits excellent bench stability, tolerates diverse functional groups, and facilitates straightforward derivatization via standard amide or ester formation—ideal for lead optimization campaigns.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H314
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
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Lot numbers can be found on the outside label of a product: