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CS-W001157 4
Total: USD 88.00

2-Fluoro-3-methoxypyridine

  • CAS No. 163234-74-0

  • Cat. No. CS-0097752
  • Purity≥98%
  • MDL No.MFCD09834126

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-3-methoxypyridine|CS-0097752

Structure of 163234-74-0

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General Information

  • CAS No. 163234-74-0
  • Cat. No. CS-0097752
  • Purity ≥98%
  • MDL No. MFCD09834126
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆FNO
  • Molecular Weight 127.12
  • Synonym(s) Pyridine, 2-fluoro-3-methoxy- (9CI)
  • SMILES COC1=CC=CN=C1F

Description

2-Fluoro-3-methoxypyridine is a bench-stable heterocyclic building block featuring a fluorine atom at the 2-position and a methoxy group at the 3-position, enabling selective functionalization in synthetic pathways. This electron-deficient pyridine derivative integrates efficiently into pharmaceutical intermediates and agrochemical scaffolds, offering enhanced reactivity under standard conditions.

Application

2-Fluoro-3-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the electron-deficient C2 position via palladium-catalyzed cross-coupling. The methoxy group provides orthogonal reactivity and enhances solubility, while the fluorine substituent offers favorable metabolic stability and modulates electronic properties. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient synthesis of complex heterocyclic scaffolds and API intermediates.

Synthesis

  • Route1
    • In-stock
      2-Fluoro-3-hydroxypyridine|CS-W019913
      174669-74-0
    • null|null
      74-88-4
    • ~97%
    • In-stock
      2-Fluoro-3-methoxypyridine|CS-0097752
      163234-74-0

    References

    • Ma, Yongmin; Roy, Sourav; Kong, Xiaole; Chen, Yulin; Liu, Dingyong; Hider, Robert C. Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2185 - 2195
  • Route2

    References

    • LaBeaume, Paul; Placzek, Michael; Daniels, Mathew; Kendrick, Ian; Ng, Patrick; McNeel, Melissa; Afroze, Roushan; Alexander, Abigail; Thomas, Rhiannon; Kallmerten, Amy E.; Jones, Graham B. Tetrahedron Letters, 2010 , vol. 51, # 14 p. 1906 - 1909
  • Route3
    • null|null
      372-48-5
    • ~%
    • In-stock
      2-Fluoro-3-methoxypyridine|CS-0097752
      163234-74-0

    References

    • Journal of Medicinal Chemistry, , vol. 55, # 5 p. 2185 - 2195

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   1.2293
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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