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CS-W001157 4
Total: USD 88.00

1,4-Butane sultone

  • CAS No. 1633-83-6

  • Cat. No. CS-W018691
  • Purity≥98%
  • MDL No.MFCD00006584

*For research and further manufacturing use only, not for direct human use.

1,4-Butane sultone|CS-W018691

Structure of 1633-83-6

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General Information

  • CAS No. 1633-83-6
  • Cat. No. CS-W018691
  • Purity ≥98%
  • MDL No. MFCD00006584
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈O₃S
  • Molecular Weight 136.17
  • Synonym(s) None
  • SMILES O=S1(CCCCO1)=O

Description

The side-chain Mtt group can be selectively removed with 1% TFA in DCM [1,2,3] or DCM/HFIP/TFE/TES (6.5:2:1:0.5) [4], making this an excellent derivative for the synthesis by Fmoc SPPS of branched peptides and peptides modified at the Dab side-chain [4,5], and for the construction of templates and multifunctionalized resins for combinatorial synthesis. Associated Protocols and Technical ArticlesCleavage and Deprotection Protocols for Fmoc SPPSLiterature references[1] K. Barlos, et al., C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden, 1993, pp. 283. [2] A. Aletras, et al. (1995) Int. J. Peptide Protein Res., 45, 488. [3] L. Bourel, et al. (2000) J. Peptide Sci., 6, 264. [4] K. Barlos, personal communication. [5] P. Hoogerhout, et al. (1999) J. Peptide Res., 54, 436. [6] C. Park & K. Burgess (2001) J. Comb. Chem., 3, 257.

Synthesis

  • Route1
    • 4-Mercaptobutan-1-ol|CS-0621767
      14970-83-3
    • ~26%
    • In-stock
      1,4-Butane sultone|CS-W018691
      1633-83-6
    • In-stock
      4-Chloro-1-butylsulfonyl Chloride|CS-0696508
      1633-84-7

    References

    • King, J. F.; Webster, Michael R.; Chiba, Naoki; Allen, Julie K.; Parker, Kenneth J. M.; et al. Phosphorus and Sulfur and the Related Elements, 1987 , vol. 31, p. 161 - 176
  • Route2
    • 4-Mercaptobutan-1-ol|CS-0621767
      14970-83-3
    • ~11%
    • In-stock
      1,4-Butane sultone|CS-W018691
      1633-83-6
    • In-stock
      4-Chloro-1-butylsulfonyl Chloride|CS-0696508
      1633-84-7
    • null|null
      113309-30-1

    References

    • Phosphorus and Sulfur and the Related Elements, , vol. 31, p. 161 - 176
  • Route3

    References

    • Phosphorus and Sulfur and the Related Elements, , vol. 31, p. 161 - 176

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS08
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H317-H319-H335-H351
Precautionary Statements : P261-P264-P270-P271-P272-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.37
  • LogP   0.1266
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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