(3S)-3-(Difluoromethyl)pyrrolidine hydrochloride

Name: (3S)-3-(Difluoromethyl)pyrrolidine hydrochloride
Brand: ChemScene
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CAS No. 1638744-40-7
Cat. No. CS-0184109
Purity≥95%
MDL No.MFCD28501341

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(3S)-3-(Difluoromethyl)pyrrolidine hydrochloride|CS-0184109

Structure of 1638744-40-7

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Description

This difluoromethyl-substituted pyrrolidine hydrochloride features a conformationally constrained heterocycle with enhanced metabolic stability. The electron-withdrawing difluoromethyl group modulates basicity and lipophilicity, enabling improved membrane permeability. This bench-stable salt form facilitates handling in synthetic workflows, particularly in medicinal chemistry campaigns targeting CNS-penetrant molecules.

Application

(3S)-3-(Difluoromethyl)pyrrolidine hydrochloride serves as a versatile chiral building block in medicinal chemistry, enabling the introduction of a difluoromethyl group at the pyrrolidine C3 position. Its bench-stable hydrochloride salt form facilitates handling and purification, while the stereodefined (3S) configuration supports predictable reactivity in asymmetric synthesis. The difluoromethyl moiety enhances metabolic stability and modulates lipophilicity, making this scaffold valuable for optimizing pharmacokinetic properties in bioactive molecules.

General Information

CAS No. 1638744-40-7
Cat. No. CS-0184109
Purity ≥95%
MDL No. MFCD28501341
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₁₀ClF₂N
Molecular Weight 157.59
Synonym(s) None
SMILES FC([C@@H]1CNCC1)F.[H]Cl

Computational Chemistry Data

TPSA 12.03
LogP 1.2828
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(3S)-3-(Difluoromethyl)pyrrolidine hydrochloride

CAS No. 1638744-40-7

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