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Benzyl 3-formylazetidine-1-carboxylate

  • CAS No. 1638761-59-7

  • Cat. No. CS-0433222
  • Purity≥95%
  • MDL No.MFCD17170763

*For research and further manufacturing use only, not for direct human use.

Benzyl 3-formylazetidine-1-carboxylate|CS-0433222

Structure of 1638761-59-7

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General Information

  • CAS No. 1638761-59-7
  • Cat. No. CS-0433222
  • Purity ≥95%
  • MDL No. MFCD17170763
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₃NO₃
  • Molecular Weight 219.24
  • Synonym(s) 1-Cbz-azetidine-3-carbaldehyde
  • SMILES O=C(N1CC(C=O)C1)OCC2=CC=CC=C2

Description

Benzyl 3-formylazetidine-1-carboxylate features a reactive aldehyde group on a strained azetidine ring, enabling direct incorporation into diverse heterocyclic scaffolds. This bench-stable reagent facilitates efficient coupling reactions and serves as a key intermediate in the synthesis of bioactive nitrogen-containing compounds.

Application

Benzyl 3-formylazetidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to azetidine-containing scaffolds. The formyl group facilitates nucleophilic addition and reductive amination reactions, while the benzyl ester offers convenient protection and orthogonal deprotection. Its stability under standard handling conditions and compatibility with diverse functional groups make it well-suited for iterative synthesis and library generation.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   46.61
  • LogP   1.4539
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

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