2'-O-MOE-5MeU-3'-phosphoramidite

Name: 2'-O-MOE-5MeU-3'-phosphoramidite
Brand: ChemScene
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CAS No. 163878-63-5
Cat. No. CS-0023725
Purity≥97%
MDL No.MFCD11505865

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Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2'-O-MOE-5MeU-3'-phosphoramidite|CS-0023725

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General Information

CAS No. 163878-63-5
Cat. No. CS-0023725
Purity ≥97%
MDL No. MFCD11505865
Storage -20°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄₃H₅₅N₄O₁₀P
Molecular Weight 818.89
Synonym(s) None
SMILES CC(C)N(C(C)C)P(O[C@H]1[C@@H](OCCOC)[C@H](N(C(N2)=O)C=C(C)C2=O)O[C@@H]1COC(C3=CC=CC=C3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)OCCC#N

Description

2'-O-MOE-5MeU-3'-phosphoramidite integrates a 5-methyluracil base with a 2'-O-methoxyethyl modification, delivering enhanced nuclease resistance and improved binding affinity. This phosphoramidite enables efficient incorporation during solid-phase oligonucleotide synthesis, streamlining the production of modified antisense agents with superior stability and target engagement.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

TPSA 155.73
LogP 6.4611
H_Acceptors 13
H_Donors 1
Rotatable_Bonds 21

Other Classifications

Life Science Nucleosides & Nucleotides 2'-O-MOE-phosphoramidite monomer

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Chemical Biology Pharmaceutical Development and Drug Discovery Research Nucleic Acid Chemistry Nucleoside Phosphoramidites

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Nucleic Acid Chemistry Nucleoside Phosphoramidites

Chemical Biology Nucleic Acid Chemistry Methylated Nucleosides

Chemical Biology Nucleic Acid Chemistry Nucleoside Phosphoramidites

Key Words

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2'-O-MOE-5MeU-3'-phosphoramidite

CAS No. 163878-63-5

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