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CS-W001157 4
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(2R,5R)-2,5-Dimethylmorpholine hydrochloride

  • CAS No. 1639886-52-4

  • Cat. No. CS-0158230
  • Molecule weight151.63
  • Purity≥97%
  • MDL No.MFCD22199177

*For research and further manufacturing use only, not for direct human use.

(2R,5R)-2,5-Dimethylmorpholine hydrochloride|CS-0158230

Structure of 1639886-52-4

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General Information

  • CAS No. 1639886-52-4
  • Cat. No. CS-0158230
  • Purity ≥97%
  • MDL No. MFCD22199177
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₄ClNO
  • Molecular Weight 151.63
  • Synonym(s) None
  • SMILES C[C@@H]1CO[C@H](C)CN1.Cl

Description

(2R,5R)-2,5-Dimethylmorpholine hydrochloride is a chiral, bench-stable heterocyclic salt featuring a rigidified piperidine-like core. This configuration enhances stereochemical control in asymmetric synthesis, enabling selective functionalization at the 2- and 5-positions. The hydrochloride form improves solubility and handling in aqueous reaction media.

Application

(2R,5R)-2,5-Dimethylmorpholine hydrochloride serves as a stereochemically defined, bench-stable chiral auxiliary in asymmetric synthesis. Its constrained conformation facilitates stereoselective transformations, particularly in nucleophilic additions and reductive amination protocols. The hydrochloride salt enhances solubility and simplifies handling, enabling efficient incorporation into multi-step sequences for heterocyclic and medicinal chemistry applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   0.805
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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