(3,5-Dichloro-4-fluorophenyl)boronic acid

Name: (3,5-Dichloro-4-fluorophenyl)boronic acid
Brand: ChemScene
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CAS No. 1646614-31-4
Cat. No. CS-0135418
Purity≥97%
MDL No.MFCD18837599

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(3,5-Dichloro-4-fluorophenyl)boronic acid|CS-0135418

Structure of 1646614-31-4

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Description

This boronate moiety features a trifluorinated aryl core with orthogonal halogen substituents, enabling selective cross-coupling under mild conditions. The electron-deficient ring enhances reactivity in Suzuki-Miyaura protocols, while the bench-stable nature simplifies handling and storage.

Application

(3,5-Dichloro-4-fluorophenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. The ortho-difluoro substitution pattern enhances metabolic stability and modulates electronic properties, making it valuable for constructing bioactive heterocycles and pharmaceutical intermediates. Bench-stable and readily purified by recrystallization, it exhibits broad functional group tolerance and compatibility with diverse coupling partners.

General Information

CAS No. 1646614-31-4
Cat. No. CS-0135418
Purity ≥97%
MDL No. MFCD18837599
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄BCl₂FO₂
Molecular Weight 208.81
Synonym(s) 3,5-Dichloro-4-fluorophenylboronic acid
SMILES OB(C1=CC(Cl)=C(F)C(Cl)=C1)O

Computational Chemistry Data

TPSA 40.46
LogP 0.8123
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Boronic Acid And Its Ester

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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(3,5-Dichloro-4-fluorophenyl)boronic acid

CAS No. 1646614-31-4

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