(R)-tBu-Phox

Name: (R)-tBu-Phox
Brand: ChemScene
Availability: InStock
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CAS No. 164858-79-1
Cat. No. CS-0088022
Purity≥95%
MDL No.MFCD06799049

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Structure of 164858-79-1

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Description

(R)-tBu-Phox is a bench-stable, sterically hindered chiral phosphine ligand featuring a bulky tert-butyl group and a phenyl moiety. This configuration enhances enantioselectivity in palladium-catalyzed cross-coupling reactions, enabling efficient asymmetric synthesis under standard conditions.

Application

(R)-tBu-Phox serves as a highly effective chiral ligand in palladium-catalyzed cross-coupling reactions, enabling enantioselective C–C bond formation under mild conditions. Its bulky tert-butyl group enhances steric control and improves catalyst stability, while the phosphine oxide functionality facilitates ligand coordination and ease of purification. This robust configuration supports high enantiomeric excess in Suzuki-Miyaura and Negishi couplings, making (R)-tBu-Phox a reliable choice for asymmetric synthesis in pharmaceutical and agrochemical R&D.

General Information

CAS No. 164858-79-1
Cat. No. CS-0088022
Purity ≥95%
MDL No. MFCD06799049
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₅H₂₆NOP
Molecular Weight 387.45
Synonym(s) (4S)-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole
SMILES CC(C)(C)[C@H](CO1)N=C1C2=C(P(C3=CC=CC=C3)C4=CC=CC=C4)C=CC=C2

Computational Chemistry Data

TPSA 21.59
LogP 4.6363
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 4

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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(R)-tBu-Phox

CAS No. 164858-79-1

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