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CS-W001157 4
Total: USD 88.00

2-Bromo-3-phenylpropanoic acid

  • CAS No. 16503-53-0

  • Cat. No. CS-0060520
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Bromo-3-phenylpropanoic acid|CS-0060520

Structure of 16503-53-0

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Description

2-Bromo-3-phenylpropanoic acid features a brominated aliphatic chain flanked by a phenyl group and a carboxylic acid, enabling direct functionalization in cross-coupling and conjugate addition reactions. This sterically defined scaffold delivers high reactivity under mild conditions, facilitating the synthesis of bioactive analogs and complex molecular architectures in medicinal chemistry workflows.

Application

2-Bromo-3-phenylpropanoic acid serves as a versatile building block for the synthesis of β-aryl-α-halo carboxylic acid derivatives. Its bromine substituent enables subsequent palladium-catalyzed cross-coupling reactions, while the phenyl group provides structural rigidity and electronic modulation. The carboxylic acid functionality facilitates direct derivatization or activation for amide bond formation. This compound exhibits good bench stability and is compatible with standard purification methods, making it suitable for iterative synthetic sequences in medicinal chemistry and process development workflows.

General Information

  • CAS No. 16503-53-0
  • Cat. No. CS-0060520
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉BrO₂
  • Molecular Weight 229.07
  • Synonym(s) 2-BROMO-3-PHENYL-PROPIONIC ACID
  • SMILES C1=CC=C(C=C1)CC(C(=O)O)Br

Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.0772
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   3

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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