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Structure of 165250-69-1
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4-Methyl-5-nitro-1H-indole features a fused bicyclic scaffold with complementary electron-deficient and alkylated sites, enabling direct incorporation into heterocyclic architectures. The para-nitro group enhances reactivity in cross-coupling processes, while the methyl substituent provides steric stabilization. This bench-stable compound serves as a key intermediate in medicinal chemistry campaigns targeting kinase inhibitors and bioactive nitrogen heterocycles.
4-Methyl-5-nitro-1H-indole serves as a versatile building block for medicinal chemistry and heterocyclic synthesis, enabling direct functionalization at the C4 position via cross-coupling or electrophilic substitution. The nitro group facilitates subsequent reduction to an amine, while the methyl substituent enhances metabolic stability and modulates electronic properties. This compound exhibits good bench stability and is compatible with standard purification protocols, making it ideal for iterative synthesis of indole-based scaffolds in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: