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Structure of 166170-15-6
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1-Boc-2-methyl-D-proline is a bench-stable, moisture-tolerant proline derivative featuring a tert-butoxycarbonyl group at the N-terminus and a methyl substituent at the C-2 position. This configuration enhances conformational rigidity and stereochemical integrity, enabling reliable incorporation into peptide chains during solid-phase synthesis. The protected amine facilitates sequential coupling without racemization, while the sterically hindered side chain improves selectivity in complex macrocyclization reactions.
1-Boc-2-methyl-D-proline serves as a stable, bench-friendly building block for peptide synthesis and medicinal chemistry. The Boc group provides reliable protection of the α-amino functionality, while the 2-methyl substituent introduces conformational rigidity to D-proline scaffolds. It facilitates efficient coupling reactions with minimal racemization and enables incorporation into peptidomimetics, heterocyclic systems, and bioactive macrocycles where steric and stereochemical control are critical.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: