Lot numbers can be found on the outside label of a product:
1H-Indole-2-carboxamide
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CAS No. 1670-84-4
- Cat. No. CS-0149972
- Purity≥98%
- MDL No.MFCD00231036
*For research and further manufacturing use only, not for direct human use.
Structure of 1670-84-4
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General Information
- CAS No. 1670-84-4
- Cat. No. CS-0149972
- Purity ≥98%
- MDL No. MFCD00231036
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₈N₂O
- Molecular Weight 160.17
- Synonym(s) Indole-2-carboxaMide(6CI,7CI,8CI)
- SMILES NC(C1=CC2=CC=CC=C2N1)=O
Description
1H-Indole-2-carboxamide serves as a privileged scaffold in medicinal chemistry, featuring a planar indole core with a carboxamide group at the C2 position. This moiety integrates readily into bioactive molecules, offering favorable hydrogen-bonding capacity and metabolic stability for drug discovery applications.
Application
1H-Indole-2-carboxamide serves as a versatile scaffold in medicinal chemistry, enabling efficient access to diverse heterocyclic architectures. Its amide functionality offers enhanced solubility and hydrogen-bonding capacity, while the indole core provides structural rigidity and π-electron delocalization. The compound exhibits robust bench stability and facilitates straightforward derivatization via standard coupling reactions, making it a practical building block for targeted synthesis of bioactive molecules and API intermediates.
Synthesis
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Route1
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In-stock
1477-50-5 - ~90%
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In-stock
1670-84-4
References
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RICHTER GEDEON VEGYESZETI GYAR RT. Patent: WO2006/10965 A1, 2006 ; Location in patent: Page/Page column 13 ; WO 2006/010965 A1
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Route2
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58881-45-1 - ~%
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In-stock
1670-84-4
References
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Arkiv foer Kemi, , vol. 10, p. 179
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Route3
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In-stock
4551-72-8 - ~53%
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In-stock
1670-84-4
References
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Leftheris, Katerina; Zhao, Rulin; Chen, Bang-Chi; Kiener, Peter; Wu, Hong; Pandit, Chennagiri R.; Wrobleski, Stephen; Chen, Ping; Hynes, John; Longphre, Malinda; Norris, Derek J.; Spergel, Steven Patent: US2002/119972 A1, 2002 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Quality Control
Computational Chemistry Data
- TPSA 58.88
- LogP 1.2668
- H_Acceptors 1
- H_Donors 2
- Rotatable_Bonds 1
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Key Words
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