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Structure of 16732-64-2
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4-Bromo-1H-indole-2-carboxylic acid features a bromine substituent at the 4-position and a carboxylic acid group at C2, enabling direct functionalization in heterocyclic synthesis. This electron-deficient indole scaffold integrates readily into bioactive molecule frameworks, particularly in medicinal chemistry campaigns targeting kinase inhibitors and receptor modulators. The carboxylic acid facilitates derivatization via amide coupling or esterification under standard conditions.
4-Bromo-1H-indole-2-carboxylic acid serves as a versatile building block for the synthesis of biologically active indole derivatives. The bromo group enables palladium-catalyzed cross-coupling reactions, while the carboxylic acid facilitates amide bond formation and derivatization. Its bench-stable nature and compatibility with standard protecting group strategies make it well-suited for medicinal chemistry campaigns and API intermediate development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: