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CS-W001157 4
Total: USD 88.00

4-Hydroxy-1-methylquinolin-2(1H)-one

  • CAS No. 1677-46-9

  • Cat. No. CS-0131691
  • Purity≥95%
  • MDL No.MFCD00024052

*For research and further manufacturing use only, not for direct human use.

4-Hydroxy-1-methylquinolin-2(1H)-one|CS-0131691

Structure of 1677-46-9

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General Information

  • CAS No. 1677-46-9
  • Cat. No. CS-0131691
  • Purity ≥95%
  • MDL No. MFCD00024052
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉NO₂
  • Molecular Weight 175.18
  • Synonym(s) 4-HYDROXY-N-METHYL-2-QUINOLONE
  • SMILES O=C1N(C)C2=C(C=CC=C2)C(O)=C1

Application

4-Hydroxy-1-methylquinolin-2(1H)-one serves as a versatile scaffold in medicinal chemistry, enabling efficient access to quinoline-based bioactive compounds. Its hydroxyl and carbonyl functionalities support diverse transformations, including derivatization at C4 and N1, while maintaining bench stability and compatibility with standard coupling and protection protocols. Functions as a key building block for heterocyclic libraries and API intermediates requiring polar, hydrogen-bonding motifs.

Synthesis

  • Route1
    • null|null
      5946-42-9
    • ~78%
    • In-stock
      4-Hydroxy-1-methylquinolin-2(1H)-one|CS-0131691
      1677-46-9

    References

    • Dittmer, Donald C.; Li, Qun; Avilov, Dimitry V. Journal of Organic Chemistry, 2005 , vol. 70, # 12 p. 4682 - 4686
  • Route2
    • 3-Acetyl-4-hydroxy-1-methylquinolin-2(1H)-one|CS-0453536
      54289-76-8
    • ~93%
    • In-stock
      4-Hydroxy-1-methylquinolin-2(1H)-one|CS-0131691
      1677-46-9

    References

    • Razzaq, Tahseen; Kappe, C. Oliver Tetrahedron Letters, 2007 , vol. 48, # 14 p. 2513 - 2517
  • Route3
    • In-stock
      2-(Methylamino)benzoic acid|CS-W021445
      119-68-6
    • null|null
      108-24-7
    • ~69%
    • In-stock
      4-Hydroxy-1-methylquinolin-2(1H)-one|CS-0131691
      1677-46-9

    References

    • Pirrung, Michael C.; Blume, Florian Journal of Organic Chemistry, 1999 , vol. 64, # 10 p. 3642 - 3649

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   42.23
  • LogP   1.2441
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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