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2-(Piperidin-3-yl)ethan-1-ol hydrochloride

  • CAS No. 16780-04-4

  • Cat. No. CS-D1062
  • Purity≥95%
  • MDL No.MFCD14583117

*For research and further manufacturing use only, not for direct human use.

2-(Piperidin-3-yl)ethan-1-ol hydrochloride|CS-D1062

Structure of 16780-04-4

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General Information

  • CAS No. 16780-04-4
  • Cat. No. CS-D1062
  • Purity ≥95%
  • MDL No. MFCD14583117
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₆ClNO
  • Molecular Weight 165.66
  • Synonym(s) 2-(3-Piperidyl)ethanol hydrochloride
  • SMILES OCCC1CNCCC1.Cl

Description

This piperidinyl-ethyl alcohol hydrochloride features a tertiary amine scaffold with a pendant hydroxyl group, enabling dual hydrogen-bonding capacity and enhanced solubility. The protonated piperidine ring improves aqueous compatibility while maintaining metabolic stability. This bifunctional moiety integrates efficiently into bioactive scaffolds for medicinal chemistry applications.

Application

2-(Piperidin-3-yl)ethan-1-ol hydrochloride serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard amine functionalization and cyclization protocols. The piperidine core offers favorable solubility and metabolic stability, while the primary alcohol facilitates derivatization via esterification or ether formation. Bench-stable and readily purified by recrystallization, it functions effectively in multistep synthesis workflows requiring moderate basicity and controlled reactivity.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   32.26
  • LogP   0.7902
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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