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CS-W001157 4
Total: USD 88.00

NHS-PEG1-SS-PEG1-NHS

  • CAS No. 1688598-83-5

  • Cat. No. CS-0127965
  • Purity≥98%
  • MDL No.MFCD32644554

*For research and further manufacturing use only, not for direct human use.

NHS-PEG1-SS-PEG1-NHS|CS-0127965

Structure of 1688598-83-5

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General Information

  • CAS No. 1688598-83-5
  • Cat. No. CS-0127965
  • Purity ≥98%
  • MDL No. MFCD32644554
  • Storage 4°C, stored under nitrogen, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₆N₂O₁₀S₂
  • Molecular Weight 436.41
  • Synonym(s) None
  • SMILES O=C1CCC(N1OC(OCCSSCCOC(ON2C(CCC2=O)=O)=O)=O)=O

Description

NHS-PEG1-SS-PEG1-NHS is a cleavable, bis-electrophilic linker designed for site-specific conjugation in bioconjugate chemistry. The central disulfide bond enables reduction-sensitive cleavage under physiological conditions, while the terminal NHS esters facilitate efficient coupling to primary amines on proteins or biomolecules. This structure supports reversible immobilization and controlled release in drug delivery and diagnostic applications.

Application

NHS-PEG1-SS-PEG1-NHS is a cleavable, bis-active ester linker designed for site-specific conjugation in bioconjugation workflows. The disulfide bond enables reduction-sensitive cleavage under physiological conditions, while the terminal NHS esters facilitate efficient coupling to primary amines on proteins, antibodies, or biomolecules. Offers excellent stability in storage and solution, with straightforward purification via standard protocols. Functions as a robust scaffold for antibody-drug conjugate (ADC) synthesis and targeted delivery systems.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   145.82
  • LogP   0.8022
  • H_Acceptors   12
  • H_Donors   0
  • Rotatable_Bonds   9

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