Methyl 2-(3-fluoro-4-nitrophenyl)acetate

Name: Methyl 2-(3-fluoro-4-nitrophenyl)acetate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 169339-41-7
Cat. No. CS-0149325
Molecule weight213.16
Purity≥98%
MDL No.MFCD16620330

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Methyl 2-(3-fluoro-4-nitrophenyl)acetate|CS-0149325

Structure of 169339-41-7

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 169339-41-7
Cat. No. CS-0149325
Purity ≥98%
MDL No. MFCD16620330
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₈FNO₄
Molecular Weight 213.16
Synonym(s) Benzeneacetic acid, 3-fluoro-4-nitro-, methyl ester
SMILES O=C(OC)CC1=CC=C([N+]([O-])=O)C(F)=C1

Description

Methyl 2-(3-fluoro-4-nitrophenyl)acetate features a fluorinated aryl ring paired with a nitro group, enabling strong electron-withdrawing effects that enhance reactivity in cross-coupling and nucleophilic substitution processes. The ester functionality provides solubility in common organic solvents and facilitates downstream derivatization under standard conditions.

Application

Methyl 2-(3-fluoro-4-nitrophenyl)acetate serves as a versatile building block for nitroaryl-containing heterocycles and pharmaceutical intermediates. The ortho-fluoro and para-nitro groups enable sequential functionalization via palladium-catalyzed cross-coupling and in situ reduction, while the ester moiety supports hydrolysis or nucleophilic substitution. Bench-stable and compatible with standard synthetic workflows, it facilitates efficient access to bioactive scaffolds in medicinal chemistry.

Synthesis

Route1
- In-stock
  
  64123-77-9
- ~73%
- In-stock
  
  169339-41-7
References
- DIGITALBIOTECH CO., LTD. Patent: WO2005/3084 A1, 2005 ; Location in patent: Page 24; 71-72 ; WO 2005/003084 A1
Route2
- In-stock
  
  64123-77-9
- ~17%
- In-stock
  
  29640-99-1
- In-stock
  
  169339-41-7
References
- Zhu, Jieping; Beugelmans, Rene; Bourdet, Sebastien; Chastanet, Jacqueline; Roussi, George Journal of Organic Chemistry, 1995 , vol. 60, # 20 p. 6389 - 6396

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 69.44
LogP 1.4494
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 3

Other Classifications

Building Blocks Functional Group Nitro compounds

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

Methyl 2-(3-fluoro-4-nitrophenyl)acetate sigmaMethyl 2-(3-fluoro-4-nitrophenyl)acetate manufacturerMethyl 2-(3-fluoro-4-nitrophenyl)acetate priceMethyl 2-(3-fluoro-4-nitrophenyl)acetate structureMethyl 2-(3-fluoro-4-nitrophenyl)acetate SDSbuy Methyl 2-(3-fluoro-4-nitrophenyl)acetateMethyl 2-(3-fluoro-4-nitrophenyl)acetate supplierMethyl 2-(3-fluoro-4-nitrophenyl)acetate usesMethyl 2-(3-fluoro-4-nitrophenyl)acetate molecular weightprice of Methyl 2-(3-fluoro-4-nitrophenyl)acetateMethyl 2-(3-fluoro-4-nitrophenyl)acetate chemical name formula of Methyl 2-(3-fluoro-4-nitrophenyl)acetate

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

Methyl 2-(3-fluoro-4-nitrophenyl)acetate

CAS No. 169339-41-7

Recommended Products