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Structure of 1695621-65-8
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4-Chloro-2-cyclopropyl-6-fluoroquinazoline features a sterically hindered quinazoline core with electron-withdrawing chlorine and fluorine substituents, enabling robust integration into kinase inhibitor scaffolds. The cyclopropyl group enhances metabolic stability and membrane permeability, while the fused heterocyclic system provides a rigid platform for targeted molecular recognition in medicinal chemistry applications.
4-Chloro-2-cyclopropyl-6-fluoroquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient construction of kinase inhibitor scaffolds. Its orthogonal functionalization sites—reactive chlorine at C4 and fluoro group at C6—facilitate palladium-catalyzed cross-coupling and nucleophilic substitution reactions. The cyclopropyl substituent enhances metabolic stability and modulates lipophilicity, improving pharmacokinetic profiles. This compound exhibits excellent bench stability and is readily purified by chromatography, making it well-suited for high-throughput synthesis and API development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: