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Structure of 169673-92-1
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7-Chloro-6-fluoro-1H-indole is a fluorinated indole scaffold featuring orthogonal halogen substituents at the 6- and 7-positions, enabling selective functionalization in late-stage diversification. This electron-deficient heterocycle integrates readily into bioactive molecule architectures, particularly in medicinal chemistry campaigns targeting kinase inhibitors and CNS modulators.
7-Chloro-6-fluoro-1H-indole serves as a valuable building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard electrophilic substitution and cross-coupling reactions. Its orthogonal halogenation pattern provides predictable regioselectivity in Pd-catalyzed transformations, while the fluorine and chlorine substituents enhance metabolic stability and modulate electronic properties. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for scalable synthesis and API intermediate development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: