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Structure of 170108-05-1
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2-Bromo-3,4-difluorobenzoic acid features a strategically positioned bromine and two fluorine substituents on the aromatic ring, enabling selective functionalization in medicinal chemistry. The carboxylic acid group provides a reactive handle for amide coupling and derivatization under standard conditions. This electron-deficient aryl scaffold integrates readily into bioactive molecules requiring halogen bonding or enhanced metabolic stability.
2-Bromo-3,4-difluorobenzoic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct incorporation of halogenated aromatic scaffolds. Its orthogonal reactivity profile facilitates palladium-catalyzed cross-coupling reactions, including Suzuki-Miyaura and Stille couplings, while the carboxylic acid group supports amide formation and derivatization. The molecule exhibits excellent bench stability, ease of purification, and compatibility with diverse functional groups, making it well-suited for modular synthesis workflows in process and discovery chemistry.
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GHS Pictogram :
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GHS No : GHS07,GHS09
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335-H411
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Precautionary Statements : P260-P264-P270-P271-P273-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P391-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: