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CS-W001157 4
Total: USD 88.00

Fmoc-D-Abu-OH

  • CAS No. 170642-27-0

  • Cat. No. CS-W004101
  • Purity≥98%
  • MDL No.MFCD00270336

*For research and further manufacturing use only, not for direct human use.

Fmoc-D-Abu-OH|CS-W004101

Structure of 170642-27-0

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General Information

  • CAS No. 170642-27-0
  • Cat. No. CS-W004101
  • Purity ≥98%
  • MDL No. MFCD00270336
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₁₉NO₄
  • Molecular Weight 325.36
  • Synonym(s) Fmoc-D-a-aminobutyric acid
  • SMILES CC[C@@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C(O)=O

Description

Fmoc-D-Abu-OH is a bench-stable, moisture-tolerant amino acid derivative featuring a fluorinated benzyl group that enhances solubility and stability during solid-phase peptide synthesis. This D-configured building block integrates efficiently into peptide chains, offering robust coupling performance and minimal racemization.

Application

Fmoc-D-Abu-OH serves as a valuable building block in solid-phase peptide synthesis, offering enhanced solubility and stability compared to its L-isomer. The Fmoc group enables orthogonal protection for amine functionalities, facilitating efficient coupling and deprotection sequences. Its D-configured aliphatic side chain provides resistance to enzymatic degradation, making it suitable for bioactive peptide design. This reagent exhibits excellent bench stability, simplifies purification, and functions reliably across standard coupling conditions.

Synthesis

  • Route1
    • In-stock
      Fmoc-Osu Amino acid impurity|CS-1733136
      82911-69-1
    • null|null
      170642-21-4
    • ~%
    • In-stock
      Fmoc-D-Abu-OH|CS-W004101
      170642-27-0

    References

    • Journal of the American Chemical Society, , vol. 119, # 4 p. 656 - 673
  • Route2
    • In-stock
      Fmoc-Osu Amino acid impurity|CS-1733136
      82911-69-1
    • null|null
      170642-21-4
    • ~%
    • null|null
      90-82-4
    • In-stock
      Fmoc-D-Abu-OH|CS-W004101
      170642-27-0

    References

    • Journal of the American Chemical Society, , vol. 117, # 32 p. 8488 - 8489

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   3.3883
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   5

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