Fmoc-Ser(Ac)-OH

Name: Fmoc-Ser(Ac)-OH
Brand: ChemScene
Availability: InStock
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CAS No. 171778-17-9
Cat. No. CS-0100968
Purity≥97%
MDL No.MFCD00077070

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 171778-17-9

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General Information

CAS No. 171778-17-9
Cat. No. CS-0100968
Purity ≥97%
MDL No. MFCD00077070
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₀H₁₉NO₆
Molecular Weight 369.37
Synonym(s) Fmoc-O-acetyl-L-serine
SMILES O=C(O)[C@H](COC(C)=O)NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Description

Fmoc-Ser(Ac)-OH is a protected serine derivative featuring an acetylated hydroxyl group and a fluorenylmethoxycarbonyl (Fmoc) N-terminal block. This combination ensures stable incorporation during solid-phase peptide synthesis, with the acetyl moiety preventing unwanted side reactions while the Fmoc group enables orthogonal deprotection. The compound exhibits excellent solubility in common organic solvents and maintains stability under standard bench conditions.

Application

Fmoc-Ser(Ac)-OH serves as a key building block in solid-phase peptide synthesis, enabling the incorporation of acetylated serine residues with high fidelity. The Fmoc group provides orthogonal protection for the amine, while the acetyl moiety stabilizes the hydroxyl functionality against side reactions. This derivative exhibits excellent bench stability, simplifies purification, and is compatible with standard coupling conditions, facilitating efficient assembly of complex peptide sequences.

Synthesis

Route1
- 31077-89-1
- In-stock
  
  73724-45-5
- ~48%
- In-stock
  
  171778-17-9
References
- Maschauer, Simone; Pischetsrieder, Monika; Kuwert, Torsten; Prante, Olaf Journal of Labelled Compounds and Radiopharmaceuticals, 2005 , vol. 48, # 10 p. 701 - 719

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 101.93
LogP 2.5414
H_Acceptors 5
H_Donors 2
Rotatable_Bonds 6

Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Serine and derivatives

Building Blocks Functional Group Fmoc

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

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Fmoc-Ser(Ac)-OH

CAS No. 171778-17-9

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