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CS-W001157 4
Total: USD 88.00

cis-3-[(Benzyloxy)methyl]cyclobutanol

  • CAS No. 172324-68-4

  • Cat. No. CS-0040837
  • Purity≥98%
  • MDL No.MFCD06657676

*For research and further manufacturing use only, not for direct human use.

cis-3-[(Benzyloxy)methyl]cyclobutanol|CS-0040837

Structure of 172324-68-4

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General Information

  • CAS No. 172324-68-4
  • Cat. No. CS-0040837
  • Purity ≥98%
  • MDL No. MFCD06657676
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₆O₂
  • Molecular Weight 192.26
  • Synonym(s) None
  • SMILES C(OCC1=CC=CC=C1)[C@@H]2C[C@H](O)C2

Description

Pomalidomide-amido-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporatess the Pomalidomide based cereblon ligand and a linker. Pomalidomide-amido-C1-Br can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1 (HY-111758). PROTAC B-Raf degrader 1 has anti-cancer activity.

Synthesis

  • Route1

    References

    • Li, Yongfeng; Mao, Shuli; Hager, Michael W.; Becnel, Kimberlynne D.; Schinazi, Raymond F.; Liotta, Dennis C. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 12 p. 3398 - 3401
  • Route2

    References

    • PFIZER LIMITED Patent: WO2006/92691 A1, 2006 ; Location in patent: Page/Page column 78 ;
  • Route3

    References

    • Kaiwar, Vijay; Reese, Colin B.; Gray, Emily J.; Neidle, Stephen Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 18 p. 2281 - 2288

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   1.9741
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   4

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