di-tert-Butyl D-glutamate hydrochloride

Name: di-tert-Butyl D-glutamate hydrochloride
Brand: ChemScene
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CAS No. 172793-31-6
Cat. No. CS-0129625
Purity≥97%
MDL No.MFCD00237068

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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di-tert-Butyl D-glutamate hydrochloride|CS-0129625

Structure of 172793-31-6

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Description

di-tert-Butyl D-glutamate hydrochloride delivers a sterically shielded, bench-stable D-amino acid derivative ideal for asymmetric synthesis and peptide backbone modification. The protected α-amino and γ-carboxyl groups enable selective coupling under mild conditions, while the hydrochloride salt enhances solubility in common organic solvents. This derivative simplifies access to D-glutamate-containing architectures in medicinal chemistry and catalyst design.

Application

di-tert-Butyl D-glutamate hydrochloride serves as a stable, bench-ready building block for peptide synthesis and medicinal chemistry applications. The di-tert-butyl protection of the glutamate side chain enables orthogonal deprotection in complex sequences, while the hydrochloride salt enhances solubility and handling. It facilitates efficient coupling reactions and is compatible with standard Fmoc-SPPS protocols, offering reliable performance in the construction of peptidomimetics and bioactive scaffolds.

General Information

CAS No. 172793-31-6
Cat. No. CS-0129625
Purity ≥97%
MDL No. MFCD00237068
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₂₆ClNO₄
Molecular Weight 295.80
Synonym(s) H-D-GLU(OTBU)-OTBU HCL
SMILES O=C(OC(C)(C)C)[C@H](N)CCC(OC(C)(C)C)=O.[H]Cl

Computational Chemistry Data

TPSA 78.62
LogP 2.1991
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 4

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

Quality Control

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Other Classifications

Life Science Amino Acids and their Derivatives Glutamic acid and derivatives

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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di-tert-Butyl D-glutamate hydrochloride

CAS No. 172793-31-6

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