Lot numbers can be found on the outside label of a product:
Ethyl 6-hydroxy-2-naphthoate
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CAS No. 17295-12-4
- Cat. No. CS-0151749
- Purity≥97%
- MDL No.MFCD07368972
*For research and further manufacturing use only, not for direct human use.
Structure of 17295-12-4
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General Information
- CAS No. 17295-12-4
- Cat. No. CS-0151749
- Purity ≥97%
- MDL No. MFCD07368972
- Storage RT, stored under nitrogen
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₃H₁₂O₃
- Molecular Weight 216.23
- Synonym(s) Ethyl6-hydroxy-2-naphtoate
- SMILES CCOC(=O)C1=CC=C2C=C(C=CC2=C1)O
Description
Ethyl 6-hydroxy-2-naphthoate features a hydroxyl group at the 6-position of the naphthoate scaffold, enhancing solubility and enabling downstream functionalization. This bench-stable derivative integrates readily into synthetic routes requiring electron-rich aromatic systems or polar handles for conjugation.
Application
Ethyl 6-hydroxy-2-naphthoate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to naphthoic acid derivatives and functionalized heterocycles. The pendant hydroxyl group facilitates selective derivatization via esterification, etherification, or oxidation, while the ethyl ester remains stable under standard reaction conditions. Its bench-stable nature and compatibility with diverse coupling and cyclization protocols make it a practical choice for medicinal chemistry campaigns and API intermediate synthesis.
Synthesis
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Route1
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64-17-5 -
In-stock
16712-64-4 - ~98%
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In-stock
17295-12-4
References
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PFIZER, INC. Patent: WO2006/40646 A1, 2006 ; Location in patent: Page/Page column 97 ;
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Route2
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In-stock
16712-64-4
- ~%
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In-stock
17295-12-4
References
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He, Lingyan; Zhang, Liang; Liu, Xiaofeng; Li, Xianghua; Zheng, Mingyue; Li, HongLin; Yu, Kunqian; Chen, Kaixian; Shen, Xu; Jiang, Hualiang; Liu, Hong Journal of Medicinal Chemistry, 2009 , vol. 52, # 8 p. 2465 - 2481
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Route3
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78119-76-3
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In-stock
17295-12-4
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84701-39-3
References
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Kopranenkov, V. N.; Makarova, E. A.; Luk'yanets, E. A. Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, # 2 p. 303 - 306 Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 2 p. 358 - 361
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 46.53
- LogP 2.7221
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 2
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