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(S)-2-Hydroxy-3-methylbutanoic acid

  • CAS No. 17407-55-5

  • Cat. No. CS-0000171
  • Molecule weight118.13
  • Purity≥97%
  • MDL No.MFCD00066443

*For research and further manufacturing use only, not for direct human use.

(S)-2-Hydroxy-3-methylbutanoic acid|CS-0000171

Structure of 17407-55-5

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General Information

  • CAS No. 17407-55-5
  • Cat. No. CS-0000171
  • Purity ≥97%
  • MDL No. MFCD00066443
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₀O₃
  • Molecular Weight 118.13
  • Synonym(s) L-alpha-Hydroxyisovaleric acid
  • SMILES O=C(O)[C@@H](O)C(C)C

Description

A useful chiral building block for peptide synthesis. Used in the preparation of the cytotoxic didemnin cyclopeptides and of the antineoplastic agent dolastatin 15.

Synthesis

  • Route1

    References

    • Honda, Yutaka; Ori, Aiichiro; Tsuchihashi, Gen-ichi Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 3 p. 1027 - 1036
  • Route2
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      1383577-36-3
    • ~%
    • In-stock
      (S)-2-Hydroxy-3-methylbutanoic acid|CS-0000171
      17407-55-5

    References

    • Tetrahedron Letters, , vol. 53, # 28 p. 3563 - 3567
  • Route3

    References

    • Phytochemistry, , vol. 72, # 16 p. 2068 - 2074

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   0.0879
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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