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Structure of 176225-09-5
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4-Fluoro-2-(trifluoromethyl)benzene-1-sulfonyl chloride is a highly reactive sulfonyl chloride featuring a fluorinated aryl ring and a trifluoromethyl group. This combination imparts enhanced electrophilicity and stability under standard conditions, enabling efficient sulfonation of nucleophiles in synthetic transformations. The molecule facilitates direct installation of sulfonyl linkages with minimal side reactions, offering precise control in complex molecule assembly.
4-Fluoro-2-(trifluoromethyl)benzene-1-sulfonyl chloride serves as a versatile sulfonylating agent for the efficient introduction of the 4-fluoro-2-(trifluoromethyl)benzenesulfonyl group into pharmaceutical intermediates and agrochemical scaffolds. Its reactivity enables selective sulfonation of nucleophiles under mild conditions, with excellent functional group tolerance and bench stability. The trifluoromethyl and fluorine substituents enhance metabolic stability and modulate electronic properties in target molecules, making it a valuable building block in medicinal chemistry.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H314
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501
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Lot numbers can be found on the outside label of a product: