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Structure of 176389-60-9
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3-(3-(Trifluoromethyl)-3H-diazirin-3-yl)benzoic acid is a photoactivatable probe featuring a trifluoromethyl-substituted diazirine ring conjugated to a benzoic acid moiety. This structure enables site-specific, UV-induced covalent labeling of proximal biomolecules. The electron-withdrawing trifluoromethyl group enhances diazirine stability while maintaining reactivity under standard irradiation conditions. The carboxylic acid functionality allows straightforward conjugation via amide bond formation, facilitating integration into peptides, proteins, or bioconjugates for crosslinking studies.
3-(3-(Trifluoromethyl)-3H-diazirin-3-yl)benzoic acid serves as a versatile photoreactive probe for covalent labeling of biomolecules. The trifluoromethyl-substituted diazirine moiety enables efficient UV-induced formation of reactive nitrenes, facilitating site-specific protein and nucleic acid crosslinking. The carboxylic acid group provides a handle for conjugation via standard amide coupling, enhancing solubility and enabling integration into peptide and small-molecule scaffolds. Its bench-stable nature and compatibility with diverse reaction conditions make it suitable for routine use in chemical biology workflows.
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GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Danger
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UN#: 1325
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Class : 4.1
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Packing Group : Ⅱ
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Hazard Statements : H228-H315-H319
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Precautionary Statements : P210-P240-P241-P264-P280-P302+P352-P362+P364-P370+P378
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Lot numbers can be found on the outside label of a product: