(2S,4R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

Name: (2S,4R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid
Brand: ChemScene
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CAS No. 176486-63-8
Cat. No. CS-W008446
Purity≥97%
MDL No.MFCD00673783

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FedEx Limited Quantities Ground	$0.00
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(2S,4R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid|CS-W008446

Structure of 176486-63-8

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Description

This fluorenylmethoxycarbonyl-protected pyrrolidine derivative features a sterically hindered, bench-stable scaffold ideal for peptide synthesis. The (2S,4R)-configured core integrates seamlessly into complex sequences, while the tert-butoxycarbonyl and fluorenylmethoxycarbonyl groups enable orthogonal protection and efficient deprotection under standard conditions.

Application

(2S,4R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid serves as a key chiral building block for the synthesis of pyrrolidine-containing peptides and heterocyclic scaffolds. The Fmoc and Boc groups provide orthogonal protection for amine and carboxylic acid functionalities, enabling sequential coupling in solid-phase peptide synthesis. Bench-stable and readily purified by standard chromatographic methods, it facilitates efficient access to bioactive compounds through established coupling protocols.

General Information

CAS No. 176486-63-8
Cat. No. CS-W008446
Purity ≥97%
MDL No. MFCD00673783
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₅H₂₈N₂O₆
Molecular Weight 452.51
Synonym(s) None
SMILES CC(C)(OC(N1C[C@H](NC(OCC2C3=CC=CC=C3C4=CC=CC=C24)=O)C[C@H]1C(O)=O)=O)C

Computational Chemistry Data

TPSA 105.17
LogP 3.9877
H_Acceptors 5
H_Donors 2
Rotatable_Bonds 4

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Bioactive Molecules Peptides

Building Blocks Functional Group Fmoc

Life Science Amino Acids and their Derivatives Proline and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Key Words

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(2S,4R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

CAS No. 176486-63-8

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